Pharmacy Curriculum Outcomes Assessment (PCOA) Practice Exam

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Ace your Pharmacy Curriculum Outcomes Assessment (PCOA) with our comprehensive practice exam quiz, tailored to help pharmacy students excel.

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By what mechanism of action (MOA) can cimetidine increase the risk of bleeding in a patient receiving Warfarin therapy?

Promotion of warfarin metabolism
Suppression of vitamin K
Inhibition of warfarin metabolism
Increase of platelet aggregation

The correct answer is: Inhibition of warfarin metabolism

Cimetidine is a medication used to decrease stomach acid production. It belongs to a class of drugs known as histamine-2 (H2) blockers. Warfarin, on the other hand, is a medication used as a blood thinner and works by inhibiting the production of clotting factors in the liver. This means that it takes longer for blood to clot, reducing the risk of blood clots. Cimetidine can increase the risk of bleeding in a patient taking Warfarin because it inhibits the metabolism of Warfarin. This means that Warfarin stays in the body for a longer period of time, increasing the blood-thinning effect and making it more difficult for the blood to clot. The other answer choices are incorrect because - A: Promotion of warfarin metabolism would decrease the risk of bleeding as it would result in Warfarin