Pharmacy Curriculum Outcomes Assessment (PCOA) Practice Exam

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In pharmacokinetics, what does the slope of a straight line plot of log k vs 1/temperature indicate?

Drugs half-life
Drug's equilibrium state
Drug's energy of activation
Drug's solubility

The correct answer is: Drug's energy of activation

The slope of a straight line plot of log k vs 1/temperature indicates the drug's energy of activation. This is because energy of activation is directly related to the rate constant, which is represented by the slope of the line. The other options are incorrect because -A: The drugs half-life is represented by the y-intercept of this plot, not the slope. -B: The equilibrium state of a drug is represented by a plateau on the plot, not the slope. -D: The drugs solubility is not related to the slope of this plot.