Pharmacy Curriculum Outcomes Assessment (PCOA) Practice Exam

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The inflammation resulting from the conversion of arachidonic acid to leukotrienes is accomplished through:

  1. Cyclooxygenase

  2. Isomerase

  3. Lipoxygenase

  4. Hydrolase

The correct answer is: Lipoxygenase

Leukotrienes are a group of inflammatory mediators derived from arachidonic acid. This conversion is facilitated by the enzyme lipoxygenase, which is responsible for the production of leukotrienes. Cyclooxygenase, isomerase, and hydrolase are not involved in this specific process and therefore are incorrect choices. Cyclooxygenase is responsible for the production of prostaglandins, while isomerase and hydrolase have other roles in biochemical reactions. Therefore, the correct answer is C.