Pharmacy Curriculum Outcomes Assessment (PCOA) Practice Exam

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Ace your Pharmacy Curriculum Outcomes Assessment (PCOA) with our comprehensive practice exam quiz, tailored to help pharmacy students excel.

Each practice test/flash card set has 50 randomly selected questions from a bank of over 500. You'll get a new set of questions each time!

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What causes nitration-mediated tissue damage during inflammation?

Hypochlorous acid
Hydrogen peroxide
Superoxide
Peroxynitrite

The correct answer is: Peroxynitrite

Peroxynitrite is a highly reactive molecule formed during inflammation when nitric oxide reacts with superoxide. Nitration-mediated tissue damage occurs when peroxynitrite reacts with tyrosine residues in proteins, causing oxidative modifications and impairing their function. Hypochlorous acid and hydrogen peroxide are also reactive molecules produced during inflammation, but they are not directly involved in nitration-mediated tissue damage. Superoxide, on the other hand, is indirectly responsible for the formation of peroxynitrite, but it is not the direct cause of the tissue damage itself. Therefore, option D is the correct answer.